Global Down Syndrome Foundation

A nonprofit organization

$23,578 raised by 60 donors

59% complete

$40,000 Goal

People with Down syndrome deserve longer and healthier lives. Please join us in making that our future. Your matching grant can help make the difference! 


“We’re so proud and honored to be members of the Global Down Syndrome Foundation. GLOBAL provides so many opportunities for our association throughout the year, which allows us to serve our families in a more meaningful way. Thank you so much to GLOBAL for all you’ve done for our community, this year and every year. You always know how to provide the support we need when we need it most. Thank you for all you do, and we’re so honored to be members of the Global Down Syndrome Foundation.” - Down Syndrome Association of Greater Saint Louis 

Giving Activity


The Global Down Syndrome Foundation (GLOBAL) is dedicated to significantly improving the lives of people with Down syndrome through RESEARCH, MEDICAL CARE, EDUCATION, and ADVOCACY.

GLOBAL is the largest non-profit in the U.S. working to save lives and dramatically improve health outcomes for people with Down syndrome. GLOBAL has established the first Down syndrome research institute supporting over 400 scientists that are now working on 4 groundbreaking clinical trials to help people with Down syndrome who also have Alzheimer’s, autoimmune conditions, and Down syndrome regression disorder. We also support over 2,200 patients with Down syndrome from 33 states and 10 countries with excellent medical care.

Working closely with Congress and the National Institutes of Health, GLOBAL is the lead advocacy organization in the U.S. for Down syndrome research and care. GLOBAL has a membership of over 100 Down syndrome organizations worldwide and is part of a network of Affiliates - the Crnic Institute for Down Syndrome, the Sie Center for Down Syndrome, and the University of Colorado Alzheimer's and Cognition Center - all on the Anschutz Medical Campus.

GLOBAL's widely circulated publications include the first-in-class clinical GLOBAL Medical Care Guidelines for Adults with Down Syndrome and its family-friendly version, Prenatal & Newborn Down Syndrome Information, and the award-winning Down Syndrome World magazine. GLOBAL also organizes the Be Beautiful Be Yourself Fashion Show, the largest Down syndrome fundraiser in the world. Visit and follow us on social media (Facebook & Twitter - @GDSFoundation; Instagram - @globaldownsyndrome).

Background Statement

The birth of Anna and John J. Sie's granddaughter, Sophia (who is now nineteen and a freshman at Regis University!), was the inspiration and catalyst for establishing the Global Down Syndrome Foundation in 2009. At the time, there was virtually no specialty pediatric medical care or research for Down syndrome in Colorado or in surrounding states.

In addition, the Sie family experienced many disturbing situations around the diagnosis, healthcare, and education of their granddaughter. Based on these experiences, the Sie's established the Linda Crnic Institute for Down Syndrome (Crnic Institute) and its medical care arm, the Anna and John J. Sie Center for Down Syndrome at the Children's Hospital Colorado (Sie Center), and later the University of Colorado Alzheimer's and Cognition Center - all on the Anschutz Medical Campus.

GLOBAL is tasked with outreach and education that creates a pipeline of dedicated researchers, medical care patients, and informed government representatives. YOUR support helps us do this day in and day out and reminds us that we are making a difference and that we are appreciated.

THANK YOU for helping us create a brighter future for the awesome people with Down syndrome we serve!

Organization Data


Organization name

Global Down Syndrome Foundation

other names


Year Established



Diseases, Disorders & Medical Disciplines


3239 E. 2nd Ave.
Denver, CO 80206

Service areas



Denver, CO, US



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